Biochem 800:

Practical Nuclear Magnetic Resonance Theory

Tuesday, Thursday 11:00 am

Fall Semester

W. Milo Westler
Rm 2221 Biochemical sciences

The lecture notes are available as PDF files.

The class is held in Biochem 2221 in the DeLuca Biochemical Sciences Building.

Course Mailing list

Scope of the course: study of multipulsed, multinuclear, and multidimensional NMR spectroscopy; emphasis on the vector and product operator formalisms for the analysis of modern pulse sequences. Course format: (2 credits) lecture and discussion; grades to be based on participation and problem sets. Topics to be covered:

The Vector Paradigm

Coherence and Magnetization

Radio Frequency (Rf) Excitation

Chemical Shifts

Signal Detection

Fourier Transformation

Coherence Transfer Pathways and Phase Cycling

Pulsed Field Gradients

Scalar Coupling

Product Operator Formalism

Coherence Transfer

Isotope Directed Editing

Two-Dimensional NMR

Multi (>2)-Dimensional NMR

1H, 13C, and 15N Triple Resonance 3d and 4d

NMR Pulse Concatenation

Sequence Optimization


Prerequisites: introductory NMR (e.g. organic chemistry), basic trigonometry, elementary physics, and physical chemistry.

Course materials: lecture notes and literature articles